High Content Screening System

Explore our high content screening platforms that are designed to provide exceptional resolution for subcellular detection automated detection and phenotyping with intact fixed or live cells.

High content screening system.

High content screening is a combination of modern cell biology with all its molecular tools with automated high resolution microscopy and robotic handling. Our high content confocal imaging systems based on the csu are the ideal solution for drug screening using elaborated 3d and live cell assay systems as well as 2d fixed samples. Since its first introduction more than a decade ago high content imaging systems have continually evolved with many improvements enabled to meet user demands of greater flexibility and the growing requirements of assays involving complex cellular disease models. With the compact and powerful cellinsight cx5 high content screening platform you can read and analyze a 96 well plate in under four minutes.

However hescs require immunofluorescence staining with stemness markers e g oct 4 prior to hcs which can be time consuming and labor intensive in this study we employed transgenic hescs with enhanced green fluorescent protein driven by stemness gene oct 4. High content screening hcs is a well established approach for the multiparametric analysis of cellular events. High content screening hcs systems can be used for high throughput screening of drugs in human embryonic stem cells hescs. An end to end solution for high content imaging and analysis.

User friendly high content analysis software cellpathfinder with its versitile functionalities powerfully supports the analysis of various phnotype changes and target. The opera phenix plus high content screening system is the premier confocal solution for today s most demanding high content applications. Simultaneous multi color imaging is a technology commonly used to increase the speed of high content screening systems. Hcs is also used to discover and optimize new drug candidates.

Designed for researchers looking to increase their screening throughput the platform offers common excitation wavelengths for fluorescence and white light illumination for colorimetric samples. Our systems for high content imaging hci and high content analysis hca provide flexible scalability making it easy to evolve your system alongside your research. They feature options and modules to address your specific research including objectives filters imaging modes and. Opera phenix high content screening system.

However one of the main problems arising from this approach is spectral crosstalk which can limit assay sensitivity.